Mrs Mason said advice villagers have had from estate agents is that property prices will be hit for a considerable distance from the proposed line. Those living closest will find their homes unsellable, she said.
The Government announced draft plans to extend the HS2 line to the north of England a week ago.
Prime Minister David Cameron said extending the already-planned London to Birmingham HS2 line as far as Manchester and Leeds would "spread wealth and prosperity" around the country.
The second phase of HS2 envisages five stops on a 211-mile Y-shaped extension northwards from Birmingham - scheduled to be completed in 2032, six years after the first phase. Officials say the £32.7 billion project will create at least 100,000 jobs and slash journey times.
The move was widely welcomed by businesses, which called on the Government to follow it up with funding for further infrastructure links within the regions.