She told Mr Salmond: "The people's priorities are jobs, paying your bills, putting food on the table. When will he realise it's not independence Scots care about, it's the economy stupid?"
Mr Salmond told her that "every single member" of his Government is focused on economic recovery.
Tory leader Ruth Davidson also hit out at the First Minister, claiming that the Scottish Government's focus on independence means that education is in "chaos" while justice is "little more than an after-thought".
Liberal Democrat leader Willie Rennie said that both health and the economy have been downgraded.